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KMID : 0381920130430040133
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Korean Journal of Microscopy
2013 Volume.43 No. 4 p.133 ~ p.139
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Effect of Pycnogenol on Skin Wound Healing
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Jeong Moon-Jin
Jeong Soon-Jeong
Lee Soo-Han
Kim Young-Soo
Choi Baik-Dong
Kim Seung-Hyun
Go Ara
Kim Se-Eun
Kang Seong-Soo
Moon Chang-Jong
Kim Jong-Choon
Kim Sung-Ho
Bae Chun-Sik
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Abstract
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This study was carried out to investigate the effects of pycnogenol (PYC) on the cutaneous wound healing of the mice. The wounds were extracted on days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area, infiltrating inflammatory cells, wound contracture including collagen deposition. As the result, the wound area of PYCtreated group was larger than the control group on days 1 to 7. Inflammatory cells in the PYC-treated wounds were decreased at day 1 compared to the control wound tissue. From day 3 to 7, there was no significant difference between the control and the PYC-treated skin wounds. Though the degree of contraction in the PYC-treated group was lower than that of the control group from days 1 to 5, but appeared significantly higher on day 7. Compared to the control group, collagen accumulation in the PYC-treated group was higher than that of the control group from days 5 to 7. From this result, it may support the possibility that PYC would be useful agent for early inflammatory response and matrix remodeling phase of the skin wounds.
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KEYWORD
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Skin wound healing, Pycnogenol, Mice
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